News Updates
MXenzyme-Reinforced Hydrogel Enhances Stem Cell Therapy Through Multidimensional Regulation in Rheumatoid Arthritis Management
Rheumatoid arthritis (RA) is a devastating autoimmune disorder that imposes health and economic burdens on communities worldwide. Although stem cell transplantation has emerged as a promising option for RA management, the osteoimmune microenvironment that characterizes elevated reactive oxygen/nitrogen species (ROS/RNS) and poor oxygen (O2) supply compromise therapeutic efficiency. To address this issue, we present a nanozyme-reinforced hydrogel designed to modulate the immune microenvironment
Stem Cell Discovery Could be Key to Tough-to-Fix Fractures
When bones break and there is extreme tissue loss—such as after a car accident or a battlefield injury—current treatments don't often lead to effective healing. But certain stem cells from skeletal muscles can improve recovery by producing all the types of cells needed to heal bones.
Research Advances in Mesenchymal Stem Cells and Related Therapies for Rotator Cuff Tendon-to-Bone Healing
Rotator cuff tears (RCTs) are a prevalent cause of shoulder dysfunction, with postoperative retearing remaining a significant challenge due to poor tendon-to-bone healing. Mesenchymal stem cells (MSCs), owing to their multipotency, immunomodulatory properties, and diverse tissue sources, have emerged as a promising therapeutic strategy.
XSTEM’s Knee Osteoarthritis Stem Cell Trial: Mid-Study Update, Safety and Positive Efficacy
Xintela has released interim data from its ongoing clinical study evaluating its stem cell product, XSTEM, in patients with knee osteoarthritis. XSTEM is an allogeneic adipose stem cell therapy, consisting of integrin selected mesenchymal stem cells. At 18 months post-treatment, the company reports demonstrated safety and positive efficacy, including statistically significant and clinically meaningful improvements in knee pain and knee function.
Global research hotspots of stem cell therapy for rotator cuff injuries: A bibliometric and visualized analysis
Stem cell therapy for rotator cuff injuries is a rapidly evolving field. Our analysis provides valuable insights into research trends and future directions, highlighting the potential of regenerative medicine and the necessity for collaborative efforts to advance this promising therapeutic approach.
Combined arthroscopic rotator cuff repair with mesenchymal stem cell augmentation shows similar functional outcomes but a higher structural integrity rate compared with isolated repair: a meta-analysis of comparative studies
Arthroscopic rotator cuff repair (RCR) has guaranteed satisfactory outcomes but remains associated with a significant rate of tendon-bone healing failure. Mesenchymal stem cells (MSCs) have been tested as a promising cell-based therapy for rotator cuff tear (RCT). MSC augmentation has been proposed as a therapy associated with surgical repair, potentially enhancing the overall surgical outcomes for patients with RCTs. The aim of this meta-analysis was to compare functional and structural outcomes between arthroscopic RCR combined with MSC augmentation vs. isolated RCR for RCT.
Biologic Therapies in the Management of Sports-Related Tendon and Ligament Injuries: A Narrative Review
Sports-related tendon and ligament injuries are common among athletes and active individuals, often resulting in prolonged recovery and compromised performance. Traditional management strategies, including physiotherapy and surgical repair, may not yield optimal outcomes, prompting growing interest in biologic therapies such as platelet-rich plasma (PRP), mesenchymal stem cells (MSCs), and other regenerative modalities.
