News Updates
Allogeneic bone marrow derived clonal mesenchymal stromal cells in refractory rheumatoid arthritis: a pilot study
BM-cMSC therapy demonstrated a favorable safety profile and potential efficacy in managing refractory RA. While preliminary results are promising, further studies with larger cohorts and long-term follow-up are needed to validate these findings and optimize therapeutic strategies.
Adipose-derived mesenchymal stem cells combined with platelet-rich plasma are superior options for the treatment of osteoarthritis
There is currently no definitive treatment for osteoarthritis. We examined the therapeutic effects and underlying mechanisms of platelet-rich plasma (PRP) and adipose-derived mesenchymal stem cells (ADSCs), individually or in combination, in a rat model of anterior cruciate ligament-induced degenerative osteoarthritis (OA) of the knee. This study seeks to advance clinical approaches to OA treatment.
Nano delivery systems in stem cell therapy: Transforming regenerative medicine and overcoming clinical challenges
Stem cell therapy has emerged as a promising approach in regenerative medicine, offering potential treatments for various degenerative diseases and injuries. However, the clinical application of stem cell therapy faces challenges such as low cell viability, inefficient delivery to target sites, and immune rejection. Nanodelivery systems (NDS) have the potential to address these limitations and enhance the efficacy of stem cell-based treatments.
Bone marrow aspirate concentrate for the treatment of fifth metatarsal head stress fracture: a case report
Metatarsal head stress fractures pose treatment challenges with no established consensus. In this article, we introduce a percutaneous treatment involving autologous bone marrow aspirate concentrate (BMAC) injection without surgical fixation in a 21-year-old basketball player with a stress fracture of the right fifth metatarsal head. He underwent this procedure following unsuccessful 8 months of conservative treatment. Twelve weeks after the procedure, a CT scan confirmed complete healing, facilitating his return to sports.
Long-term clinical and safety outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic thoracic spinal cord injury
Spinal cord injury (SCI) is a devastating condition that results in significant impairment of millions of individuals worldwide.1 Management of SCI primarily focuses on stabilizing the injury, preventing further damage, and rehabilitating the patient to potential functional recovery.2,3 Traditional treatments include surgery and neurological rehabilitation. In recent years, neuromodulation3 and cell-based therapies4 have emerged as promising procedures for SCI. Among the various types of stem cells, fetal-derived neural stem cells (NSCs) have a favorable safety profile due to their established lineage commitment potential and lack of teratoma formation.
Orthobiologics may be effective alternative to exercise therapy after rotator cuff tear
Percutaneous orthobiologic treatment may be an effective alternative to home exercise therapy for treatment of rotator cuff tears, according to results published in BMC Musculoskeletal Disorders. Bone marrow concentrate for treatment of rotator cuff tears improved patient-reported outcomes vs. home exercise therapy. MRI results also showed improvements in the orthobiologic group.
Hyaluronic acid, bone marrow aspirate concentrate provide long-term cartilage augmentation
Cartilage repair with a hyaluronic acid-based scaffold and bone marrow aspirate concentrate may yield positive long-term outcomes.
