News Updates
Nano delivery systems in stem cell therapy: Transforming regenerative medicine and overcoming clinical challenges
Stem cell therapy has emerged as a promising approach in regenerative medicine, offering potential treatments for various degenerative diseases and injuries. However, the clinical application of stem cell therapy faces challenges such as low cell viability, inefficient delivery to target sites, and immune rejection. Nanodelivery systems (NDS) have the potential to address these limitations and enhance the efficacy of stem cell-based treatments.
Bone marrow aspirate concentrate for the treatment of fifth metatarsal head stress fracture: a case report
Metatarsal head stress fractures pose treatment challenges with no established consensus. In this article, we introduce a percutaneous treatment involving autologous bone marrow aspirate concentrate (BMAC) injection without surgical fixation in a 21-year-old basketball player with a stress fracture of the right fifth metatarsal head. He underwent this procedure following unsuccessful 8 months of conservative treatment. Twelve weeks after the procedure, a CT scan confirmed complete healing, facilitating his return to sports.
Long-term clinical and safety outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic thoracic spinal cord injury
Spinal cord injury (SCI) is a devastating condition that results in significant impairment of millions of individuals worldwide.1 Management of SCI primarily focuses on stabilizing the injury, preventing further damage, and rehabilitating the patient to potential functional recovery.2,3 Traditional treatments include surgery and neurological rehabilitation. In recent years, neuromodulation3 and cell-based therapies4 have emerged as promising procedures for SCI. Among the various types of stem cells, fetal-derived neural stem cells (NSCs) have a favorable safety profile due to their established lineage commitment potential and lack of teratoma formation.
Orthobiologics may be effective alternative to exercise therapy after rotator cuff tear
Percutaneous orthobiologic treatment may be an effective alternative to home exercise therapy for treatment of rotator cuff tears, according to results published in BMC Musculoskeletal Disorders. Bone marrow concentrate for treatment of rotator cuff tears improved patient-reported outcomes vs. home exercise therapy. MRI results also showed improvements in the orthobiologic group.
Hyaluronic acid, bone marrow aspirate concentrate provide long-term cartilage augmentation
Cartilage repair with a hyaluronic acid-based scaffold and bone marrow aspirate concentrate may yield positive long-term outcomes.
Revolutionizing bone defect healing: the power of mesenchymal stem cells as seeds
Bone defects can arise from trauma or pathological factors, resulting in compromised bone integrity and the loss or absence of bone tissue. As we are all aware, repairing bone defects is a core problem in bone tissue engineering.
Hyaluronic acid, bone marrow aspirate concentrate provide long-term cartilage augmentation
Published results showed positive long-term clinical and functional outcomes for patients with knee chondral defects who underwent one-step cartilage repair with a hyaluronic acid-based scaffold and bone marrow aspirate concentrate graft.
