News Updates
Efficacy and Safety of Single Versus Repeated Injections of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Both single and repeated MSC injections could improve pain and knee joint function in patients with KOA. Compared to single injections, repeated MSC injections may offer superior therapeutic benefits; however, they are associated with a higher incidence of adverse events. In clinical practice, potential side effects of repeated MSC administration must be carefully considered. Future research should focus on large-scale, multicenter, and long-term randomized controlled trials to further validate the efficacy and safety of MSC therapy for KOA.
Mesenchymal Stem Cells Injections in Traumatology and Orthopaedics: Common Practice or Still a Promising Area with Many Uncertainties?
MSC injections represent a growing area of research in traumatology and orthopaedics. However, the results of only a small proportion of clinical trials and systematic reviews are published in peer-reviewed journals, which most likely does not allow practitioners to form a full judgement on the efficacy and safety of this treatment.
Ethical and Regulatory Considerations Related to Regenerative Medicine
The application of stem cell therapies in orthopedics holds promise for the treatment of degenerative musculoskeletal conditions. Advances in cell sourcing, differentiation protocols, and delivery methods have brought the field closer to the point-of-care application of these therapies. Personalized strategies that can target individual cell deficiencies represent the future of orthopedic regenerative medicine, offering the potential for reversing established disease and increased functional outcomes.
MXenzyme-Reinforced Hydrogel Enhances Stem Cell Therapy Through Multidimensional Regulation in Rheumatoid Arthritis Management
Rheumatoid arthritis (RA) is a devastating autoimmune disorder that imposes health and economic burdens on communities worldwide. Although stem cell transplantation has emerged as a promising option for RA management, the osteoimmune microenvironment that characterizes elevated reactive oxygen/nitrogen species (ROS/RNS) and poor oxygen (O2) supply compromise therapeutic efficiency. To address this issue, we present a nanozyme-reinforced hydrogel designed to modulate the immune microenvironment
Stem Cell Discovery Could be Key to Tough-to-Fix Fractures
When bones break and there is extreme tissue loss—such as after a car accident or a battlefield injury—current treatments don't often lead to effective healing. But certain stem cells from skeletal muscles can improve recovery by producing all the types of cells needed to heal bones.
Research Advances in Mesenchymal Stem Cells and Related Therapies for Rotator Cuff Tendon-to-Bone Healing
Rotator cuff tears (RCTs) are a prevalent cause of shoulder dysfunction, with postoperative retearing remaining a significant challenge due to poor tendon-to-bone healing. Mesenchymal stem cells (MSCs), owing to their multipotency, immunomodulatory properties, and diverse tissue sources, have emerged as a promising therapeutic strategy.
XSTEM’s Knee Osteoarthritis Stem Cell Trial: Mid-Study Update, Safety and Positive Efficacy
Xintela has released interim data from its ongoing clinical study evaluating its stem cell product, XSTEM, in patients with knee osteoarthritis. XSTEM is an allogeneic adipose stem cell therapy, consisting of integrin selected mesenchymal stem cells. At 18 months post-treatment, the company reports demonstrated safety and positive efficacy, including statistically significant and clinically meaningful improvements in knee pain and knee function.
