Orthoregeneration is defined as a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration.
Source: Springer Link
Although autologous sources are promising, there is a wide range of limitations with the treatment, including the lack of randomized controlled studies for orthopaedic conditions, donor site morbidity, and highly variable outcomes for patients. Allogenic sources bypass some of these shortcomings and are a promising source for orthopaedic regenerative medicine applications.
Repeated leukocyte-poor platelet-rich plasma injections during and after double-row suture-bridge arthroscopic rotator cuff repair may reduce the retear rate and improve Goutallier grade and clinical outcomes, according to study results.
Published results showed intraoperative injection of autologous microfragmented adipose tissue may safely and effectively improve short-term clinical and functional outcomes after single-row arthroscopic rotator cuff repair.
Source: Future Medicine
The aim of this study was to assess the benefit of stem cell therapy in the treatment of mild to severe knee osteoarthritis.
A variety of regenerative therapies, including intraarticularly applied hemo-components and cell-based therapies are currently in clinical development and are, in part, in clinical use. Such therapies face several practical opportunities and challenges and could reduce the health care burden, in part by replacing traditional drug therapies and highly invasive surgical interventions with smarter and less invasive treatments.
The aim of this systematic review is to explore the current available knowledge about tendon disorders and orthobiologics derived by preclinical experiments to evaluate their role and efficacy in the different stages and conditions related to the tendon healing processes.