Source: IFL Science
Stem cell therapy has been touted as a cure for so many conditions. Now it's time to add another one to the list.
Bone marrow aspirate concentrate augmentation of the bone-patellar tendon-bone allograft during ACL reconstruction may yield greater signal intensity scores on MRI at 3 months postoperatively, according to published results.
Rotator cuff injury is a common upper extremity musculoskeletal disease that may lead to persistent pain and functional impairment. Despite the clinical outcomes of the surgical procedures being satisfactory, the repair of the rotator cuff remains problematic, such as through failure of healing, adhesion formation, and fatty infiltration. Stem cells have high proliferation, strong paracrine action, and multiple differentiation potential, which promote tendon remodeling and fibrocartilage formation and increase biomechanical strength.
Orthoregeneration is defined as a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration.
Source: Springer Link
Although autologous sources are promising, there is a wide range of limitations with the treatment, including the lack of randomized controlled studies for orthopaedic conditions, donor site morbidity, and highly variable outcomes for patients. Allogenic sources bypass some of these shortcomings and are a promising source for orthopaedic regenerative medicine applications.
Repeated leukocyte-poor platelet-rich plasma injections during and after double-row suture-bridge arthroscopic rotator cuff repair may reduce the retear rate and improve Goutallier grade and clinical outcomes, according to study results.
Published results showed intraoperative injection of autologous microfragmented adipose tissue may safely and effectively improve short-term clinical and functional outcomes after single-row arthroscopic rotator cuff repair.