Stem Cell Therapy for Traumatic Brain Injury: Current Advances, Clinical Challenges, and Future Directions
The severity of traumatic brain injury (TBI) and its poor prognosis underscore the urgent need for more effective neuroprotective and neuroregenerative strategies. However, the pathological heterogeneity of TBI continues to hinder clinical therapeutic progress. Preclinical studies have shown that neural stem cells, through their regenerative and secretory properties, can suppress neuroinflammation and promote angiogenesis, synaptic regeneration, and neural circuit remodeling. On one hand, stem cell transplantation has entered clinical trials and demonstrates neuroprotective effects by promoting regeneration at the injury site. However, reliable evidence supporting its clinical benefits in severe TBI remains limited.
Source: ScienceDirect
